Palmatine (chloride)

ArtNr	HY-N0110-10mM
Hersteller	MedChem Express
CAS-Nr.	10605-02-4
Menge	10mM/1mL
Quantity options	10mM/1mL 1 g 250 mg
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lymphatic System Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.81
Formula	C21H22ClNO4
Citations	Biol Res. 2020 Sep 14;53(1):39. J Ethnopharmacol. 2023 Sep 27:117238. Molecules. 2024 May 14. Drug Dev Res. 2022 Aug 17. Int Immunopharmacol. 2022 Feb 9;106:108583. Oxid Med Cell Longev. 2021 Mar 13. [1]Zhang XJ, et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.Pharmacol Res. 2018 Nov;137:34-46. [2]Lee WC, et al. Palmatine attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice. Food Chem Toxicol. 2010 Jan;48(1):222-8. [3]Jia F, et al. Identification of palmatine as an inhibitor of West Nile virus. Arch Virol. 2010 Aug;155(8):1325-9. [4]Dhingra D, et al. Memory-enhancing activity of palmatine in mice using elevated plus maze and morris water maze. Adv Pharmacol Sci. 2012;2012:357368. [5]Liu X, et al. Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA. Biochem Pharmacol. 2020 May;175:113933. [6]Long J, et al. Palmatine: A review of its pharmacology, toxicity and pharmacokinetics. Biochimie. 2019 Jul;162:176-184.
Smiles	COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(OC)C=C4CC3)C=C2C=C1.[Cl-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	10605-02-4
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Aurora Kinase; Bacterial; Indoleamine 2, 3-Dioxygenase (IDO); mAChR; Parasite; Virus Protease
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	387.86
Product Description	Palmatine chloride is an orally active and irreversible indoleamine 2, 3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility	DMSO : ≥ 32 mg/mL\|H2O : 5 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Isoform	IDO1
Clinical information	Launched

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HY-N0110-10mM-safety-datasheet.pdf