trans-ACBD

Non Antibodies

NMDA receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

159, 14

An Agonist of NMDA Receptors

500 mM in H2O. Centrifuge all product preparations before use (10, 000 x g for 1 min).

41116134

trans-ACBD is an NMDA receptor agonist1, 2.

Yes

trans-ACBD is a potent, competitive and selective activator of glutamate uptake. The compound acts as an NMDA (N-methyl-D-aspartate) receptor agonist. The ACBD structure includes two isomers: cis-1-aminocyclobutane-1, 3-dicarboxylic acid and trans-1-aminocyclobutane-1, 3-dicarboxylic acid. Several studies have shown that the trans isomer is more potent than the cis isomer. The trans isomer was also shown to be 20 times more active than NMDA1, 2, the major excitatory neurotransmitter in the mammalian central nervous system (CNS).Several studies suggest that modifications and changes of glutamate uptake could play a role in processes underlying synaptic plasticity in the CNS2.NMDA receptors are ion channels gated by glutamate. Glutamate-mediated signaling is important for basic neuron-neuron signaling and neuronal processes such as learning, memory and pain perception3.