A-192621

Non Antibodies

ET-B receptor

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

558, 68

A Selective Antagonist of Endothelin B Receptors

Soluble in DMSO or NaOH 1Eq. Centrifuge all products before use (10000 x g 5 min).

41116134

A-192621 is a selective antagonist of ET-B endothelin receptors, inhibiting ET-1 binding to ETA and ET-3 binding to ETB receptors with IC50 values of 4280 nM and 4.5 nM, respectively1.In vivo, A-192621 inhibits ETB-mediated dilatory and pressor responses induced by Sarafotoxin 6c (ED50 = 30 mg/kg), and causes an elevation of arterial blood pressure and plasma ET-1 level2.

Yes

A-192621 is a synthetic compound that acts as a selective antagonist of the endothelin B (ET-B) receptor, a member of the G-protein coupled receptor (GPCR) superfamily.In vivo efficacy studies showed that A-192621 inhibits ET-1-induced dilatory and pressor responses that are mediated by ET-B. The compound can cause an increase in arterial blood pressure and plasma ET-1 levels1, 2. It inhibits ET-B receptors with an IC50 value of 4.5 nM3.ET-B receptors play an important role in regulating renal function and blood pressure and are expressed in sensory nerves. They are mainly present in medium- and large-sized cell bodies of human trigeminal ganglia4, 5.