AA 29504

Non Antibodies

GABA(A) receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

327, 43

A Positive Modulator of GABA(A) Receptors

Soluble in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).

41116134

AA 29504 is a positive allosteric modulator of GABA(A) receptors, reducing the EC50 of GABA and gaboxadol at the α4β3δ and α1β3γ2S receptors in Xenopus oocytes at over 1 µM. AA 29504, a retigabine analogue, also exhibits some agonistic activity on KCNQ channels (EC50=9.6-13.5 µM)1.

Yes

AA 29504, a close analogue of retigabine (KCNQ channel opener), acts as a positive allosteric modulator of GABA(A) receptors. A study in adult rats shows that systemic administration of AA 29504 produces anxiolytic effects and reduces motor coordination1.AA 29504 decreases the EC50 value of GABA at the GABA (A) receptors in Xenopus oocytes at over 1 µM. The compound also exhibits agonistic activity on KCNQ channels and demonstrates EC50 values of 9.6-13.5 µM1.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. These receptors mediate GABA action, a major inhibitory neurotransmitter, throughout the central nervous system (CNS). They play an important role in inhibiting cell excitation in the CNS. The GABA(A) receptor is considered to be a major target of antiseizure drugs2, 3.