A-850002

Non Antibodies

mGluR1 receptor

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

336, 41

A Selective and Potent Antagonist of mGluR1 Receptors

Up to 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

A-850002 inhibits mGluR1 in rat primary cerebellar granule neurons with an IC50 of 27 nM1 and human mGluR1 expressed in 1321N1 cells with an IC50 of 43 nM2.

Yes

A-850002 is a synthetic, selective and potent antagonist of mGluR1 receptors. It inhibits mGluR1 receptors in rat primary cerebellar granule neurons with an IC50 value of 27 nM in calcium mobilization assays and human mGluR1 receptors expressed in 1321N1 type cells with an IC50 of 43 nM1, 2.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly found on post-synaptic neurons and are known to affect the fate of neuronal progenitor cells, neural stem cells and the formation of the hippocampus3.