A-740003

Non Antibodies

P2X7 receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

474, 55

A Potent and Selective Antagonist of P2X7 Receptors

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

41116134

A-740003 is a potent and selective competitive antagonist of P2X7 receptors with IC50 values of 18 nM, 44 nM and 0.68 µM for rat, human and mouse receptors, respectively. A-740003 reduces neuropathic pain and tumor growth in vivo1, 2.

Yes

A-740003 is a potent, selective, and competitive antagonist of the P2X7 receptor, with IC50 values of 18 nM and 44 nM for rat and human P2RX7, respectively1. The compound shows weak or no activity on other P2 receptors.A-740003 has the ability to reduce neuropathic pain and tumor growth in vivo. Systemic administration of A-740003 in rat produces dose-dependent antinociception in a spinal nerve ligation model1, 2.The P2X receptor family includes seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. They are highly expressed on immune cells including glial cells, macrophages and other antigen-presenting cells1, 2.