AZD-9056 hydrochloride

Non Antibodies

P2X7 receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

455, 46

A Potent and Selective Antagonist of P2X7 Receptors

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

41116134

AZD-9056 is a potent and selective, orally bioavailable antagonist of the purinergic P2X7 receptor, shown to inhibit YoPro1 uptake in HEK-hP2X7 cells with IC50 of 11.2 nM1. AZD-9056 shows pain-relieving and anti-inflammatory effects in vivo2.

Yes

AZD-9056 hydrochloride is an adamantane amide that acts as a potent and selective antagonist of P2X7 receptors. It inhibits YoPro1 (membrane-impermeable fluorescent dye) uptake in HEK-hP2X7 cells with IC50 value of 11.2 nM1. Studies show that treatment with AZD-9056 exerts pain-relieving and anti-inflammatory effects1, 2.The P2X7 receptor is a member of the ligand-gated ion channels activated by extracellular ATP. There are seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors are highly expressed throughout autonomic, sensory and central neurons and in visceral smooth muscle, immune cells and epithelia3, 4.