A-841720

Non Antibodies

mGluR1, mGluR5

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

343, 45

An Antagonist of mGluR1 and mGluR5

Soluble in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

A-841720 is a potent and selective noncompetitive mGluR1 antagonist, acting on mGluR1 and mGluR5 with IC50 values of 10 nM and 342 nM, respectively1. In vivo it shows analgesic properties, significantly attenuating spontaneous post-operative pain behavior in rats (ED50 = 10 μMol/kg)2.

Yes

A-841720 is a potent, non-competitive antagonist of mGluR11, 2 with an IC50 of 10 nM1. At higher concentrations it also inhibits mGluR5 receptors displaying an IC50 value of 342 nM1.Glutamate is the most abundant excitatory neurotransmitter in the central nervous system. It modulates the activity of many types of synapses by activating in part metabotropic glutamate receptors (mGluRs). mGluRs consist of three groups: I, II, and III with a total of eight subtypes, mGluR1 to mGluR8. mGluR1 plays an important role in the central sensitization of pain and in a variety of functions with potential implications in neurological and psychiatric disorders1, 2.