ACT-462206

Non Antibodies

OX1, OX2 orexin receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

388, 48

A Potent Antagonist of Orexin1/2 Receptors

Soluble up to 100 mM in DMSO. Spin down all products before handling.

41116134

ACT-462206 is a potent and selective dual orexin receptor antagonist (IC50 of 60 nM and 11 nM on orexin 1 and 2 receptors, respectively). ACT-462206 is brain penetrant and orally bioavailable, demonstrating anxiolytic-like properties in rodents without affecting cognition and motor function1.

Yes

ACT-462206 is a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist with IC50 values of 60 nM and 11 nM, respectively. It has been subjected to clinical trials for use as a sleep inducer1.Orexins are highly conserved proteins known to control feeding behavior, sleep-wake rhythm, reward and addiction, and energy balance. In addition, several reports show that orexin/receptor pathways are involved in pathological processes of neurological diseases such as narcolepsy, depression, ischemic stroke, drug addiction and Alzheimer's disease2.