AZD-1332

ArtNr	ALO-A-495-5mg
Hersteller	Alomone
Menge	5 mg
Quantity options	10 mg 25 mg 50 mg 5 mg
Kategorie	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Reagents & Chemicals Molecules By Organ Thyroid Cancer
Typ	Small Molecules
Format	Lyophilized
Specific against	other
Purity	>95%
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Non Antibodies
Manufacturer - Category	S. Molecules
Manufacturer - Targets	TrkA, TrkB, TrkC receptors
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage as Solution: Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight	391, 8
Manufacturer - Format	Lyophilized Powder
Short description	A Potent and Selective Inhibitor of TrkA, TrkB, TrkC Receptors
Description	AZ-23 racemate, AZ-23 compound, 5-Chloro-2-N-[1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2, 4-diamine - A Potent and Selective Inhibitor of TrkA, TrkB, TrkC Receptors
Reconstitution	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
PH	7, 4
UNSPSC	41116134
CID	49831044
Effective Concentration	1-100 nM.
Activity	AZD-1332 is a potent, selective, and orally bioavailable inhibitor of tyrosine kinase receptors (IC50 values of
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Bioassay tested	Yes
Chemical Name	5-chloro-2-N-[1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2, 4-diamine.
Scientific Background	AZD-1332 is a potent and selective inhibitor of the Tropomyosin-related kinase (TrkA, TrkB, and TrkC) receptors. The compound is at least 30-fold more specific towards Trk in cell-based assays over a wide range of other kinases tested. AZD-1332 inhibits Trk kinase activity in cells at low nanomolar concentrations, the compound demonstrates IC50 values of

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ALO-A-495-5mg-safety-datasheet.pdf