Cl-HIBO

Non Antibodies

AMPA receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

206, 58

An Agonist of AMPA Receptors

Up to 20 mM in H2O (slow). Centrifuge all products before reconstitution (10000 x g 5 min).

41116134

Cl-HIBO is an AMPA receptor agonist, highly selective for GluR1 and GluR2 subunit-containing receptors (EC50 for rat recombinant homomeric GluR1, 2, 3 and 4 receptors are 4.7, 1.7, 2700 and 1300 μM, respectively)1.

Yes

Cl-HIBO (chloro-homoibotenic acid) acts as a full agonist at AMPA receptors (AMPARs). Cl-HIBO is the most selective agonist reported to-date for GluR1/2. Thus, the compound is considered to be a valuable tool for studying the biological behavior and distribution of AMPARs1.The ionotropic glutamate AMPA receptors are the primary receptors that mediate fast excitatory synaptic transmission in the mammalian brain. The majority of this transmission in the mammalian central nervous system is mediated by the release of glutamate from the presynaptic terminal and its binding to glutamate receptors on the postsynaptic membrane2.