Chlormethiazole hydrochloride

Non Antibodies

GABA(A), Glycine receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

198, 11

A Positive Modulator of GABA(A) and Glycine Receptors

Up to 200 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

Chlormethiazole both directly activates GABAA receptors (at 0.3 - 1 mM), and potentiates GABA-induced activation at various GABAA receptor subtypes (with EC50 of 20 - 160 µM)1. It was also shown to potentiate glycine-induced currents in both bovine chromaffin cells and murine spinal neurons (at 100 µM)2.

Yes

Chlormethiazole hydrochloride, a thiazole derivative, is a sedative, hypnotic and anxiolytic compound that has been used for the treatment of alcohol-withdrawal symptoms, status epilepticus and pre-eclampsia.Chlormethiazole acts as a positive modulator of GABA(A) and glycine receptors and holds structural similarity to the β-subunit-selective compound loreclezole. In several studies, the compound was also shown to have neuroprotective properties in models of ischaemia1, 2, 3.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels and mediate GABA action, a major inhibitory neurotransmitter, throughout the central nervous system. GABA(A) receptors are considered to be a major target of antiseizure drugs4.