Garcinolic acid

Non Antibodies

P2X7 receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

646, 78

A Positive Modulator of P2X7 Receptors

Soluble in DMSO, DMF and other organic solvents. Centrifuge all products before handling (10000 x g 5 min).

41116134

Garcinia spp.

Garcinolic acid is a natural compound isolated from Garcinia resin, shown to facilitate and potentiate cellular responses mediated by the purinergic P2X7 receptors at over 10 µM1.

Yes

Garcinolic acid, a type of xanthone, is a positive modulator of the purinergic P2X7 receptors. It facilitates and potentiates cellular responses mediated by the purinergic P2X7 receptors at concentrations over 10 µM1, 2.P2X receptors are ligand-gated cation-permeable channel complexes that are activated by extracellular ATP. This family contains seven subtypes: P2X1-P2X7 that can be assembled as trimeric complexes. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors are expressed in almost all tissues, particularly in cells of haematopoietic origin1, 3.