GW-2580

ArtNr	ALO-G-255-50mg
Hersteller	Alomone
CAS-Nr.	870483-87-7
Menge	50 mg
Quantity options	100 mg 10 mg 25 mg 50 mg 5 mg
Kategorie	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Reagents & Chemicals Molecules By Organ Thyroid Cancer
Typ	Small Molecules
Format	Lyophilized
Specific against	other
Purity	>99%
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Non Antibodies
Manufacturer - Category	S. Molecules
Manufacturer - Targets	CSF-1R receptor, Trk receptor
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage as Solution: Store at -20°C. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight	366, 41
Manufacturer - Format	Lyophilized powder.
Short description	An Inhibitor of Trk Receptors and cFMS/CSF-1 Receptor Kinases
Description	cFMS Receptor Tyrosine Kinase Inhibitor - An Inhibitor of Trk Receptors and cFMS/CSF-1 Receptor Kinases
Reconstitution	Soluble up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
PH	7, 4
UNSPSC	41116134
Effective Concentration	1-100 µM.
Activity	GW-2580 is a potent and selective inhibitor of cFMS/CSF-1 receptor kinase, shown to completely and selectively inhibit human cFMS kinase activity at 60 nM, and fully suppress CSF-1 induced cell growth at 1 μM, in vitro. Orally bioavailable and active in vivo1. GW 2580 also binds to TrkB, TrkC and TrkA with Kd values of 36 nM, 120 nM and 630 nM, respectively, 2 and fully inhibits BDNF-induced TrkB phosphorylation in cells at 3 µM3.
Solubility	Soluble up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Bioassay tested	Yes
Chemical Name	5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2, 4-diamine.
Scientific Background	GW-2580 is a small-molecule pyrimidine derivative, that acts as a potent and selective inhibitor of Colony-stimulating factor 1 (CSF-1) signaling through cFMS kinase receptor. GW-2580 completely inhibits human cFMS kinase in vitro at 0.06 μM1. The compound also acts as an inhibitor of Trk Receptors and shows binding towards TrkB, TrkC, and TrkA with Kd values of 36 nM, 120 nM and 630 nM, respectively2 and fully inhibits BDNF-induced TrkB phosphorylation in cells at 3 µM3.

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ALO-G-255-50mg-safety-datasheet.pdf