Ionomycin

ArtNr	ALO-I-700-5mg
Hersteller	Alomone
CAS-Nr.	56092-82-1
Menge	5 mg
Quantity options	10 mg 1 mg 25 mg 5 mg
Kategorie	Cell Biology Cell Status Apoptosis Cardiovascular Research Ischemia & Reperfusion Injury Reagents & Chemicals Molecules
Typ	Small Molecules
Format	Lyophilized
Specific against	other
Purity	>99% (HPLC)
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Non Antibodies
Manufacturer - Category	S. Molecules
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage as Solution: Up to two week at 4°C or three months at -20°C.Protect from light. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight	747, 08
Manufacturer - Format	Lyophilized Powder
Short description	A Potent and Selective Ca2+ Ionophore
Description	A Potent and Selective Ca2+ Ionophore
Reconstitution	DMSO or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
PH	7, 4
UNSPSC	41116134
Origin	Streptomyces conglobatus.
Effective Concentration	100 nM - 2 µM.
Activity	Ionomycin is a narrow spectrum antibiotic for gram-positive bacteria1, 2. In mammalian cells, Ionomycin acts as a selective Ca2+ ionophore3. In addition, Ionomycin induces hydrolysis of phosphoinositides, activation of PKC in human T cells as well as apoptosis in various cell lines4-6.
Solubility	DMSO or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Bioassay tested	Yes
Chemical Name	(4R, 6S, 8S, 10Z, 12R, 14R, 16E, 18R, 19R, 20S, 21S)-11, 19, 21-Tri hydroxy-4, 6, 8, 12, 14, 18, 20-heptamethyl-22-[(2S, 2'R, 5S, 5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2, 5'-dimethyl[2, 2'-bifuran]-5-yl]-9-oxo-10, 16-docosadienoic acid calcium salt.
Scientific Background	Ionomycin is a narrow spectrum antibiotic for gram-positive bacteria produced by Streptomyces conglobatus. In mammalian cells, ionomycin acts as a potent and selective Ca2+ ionophore, more effective than A23187. The Ca2+ influx by ionomycin is caused by direct stimulation of store-regulated cation entry and not by direct action at the plasma membrane.1-4Ionomycin induces hydrolysis of phosphoinositides, activation of PKC in human T cells and apoptosis in various cells lines.5-7

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