L-AP4

Non Antibodies

mGluR4, 6, 7, 8

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

183, 1

A Potent and Selective Agonist of Group III mGluRs

Up to 25 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

L-AP4 is a group III mGluR specific agonist. Reversibly depresses basal synaptic transmission in rat hippocampal slices (IC50 = 3 µM)1.

Yes

L-AP4 is a synthetic, potent and selective agonist of group III metabotropic glutamate receptors (mGluR4 and mGluR6 through mGluR8). L-AP4 also depresses basal synaptic transmission in rat hippocampal slices with an IC50 of 3 µM in a dose dependent manner. Maximum depression of 74% is obtained at a concentration of 100 µM L-AP4. A concentration of 10 µM L-AP4 induces a depression of 59% and when the mGluR antagonist MCCG is added it shows little or no effect. In contrary, the mGluR antagonists MPPG and MTPG are effective L-AP4 antagonists1.L-AP4-sensitive neuronal glutamatergic pathways include synapses of the mossy-fiber/ CA3 projection synapses of pyramidal cell projecting from the lateral olfactory tract to the pyriform cortex and synaptic contacts in the basolateral amygdala. It has also been suggested that L-AP4 sensitive receptors are important for memory and learning and might be implicated in the pathogenesis of Alzheimer's disease2.