MCI-225

Non Antibodies

5-HT3A receptor, NET transporter

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

328, 4

A Potent Antagonist of 5-HT3 Channels and a Selective Noradrenaline Reuptake Inhibitor

30 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

MCI-225 shows high affinity for the 5-HT3 receptor, Ki less than 100 nmol/L1.

Yes

MCI-225 is a psychoactive compound, a thienopyrimidine analogue that acts as a selective noradrenaline (NA) reuptake inhibitor with 5-HT3 channel blocking action. The compound demonstrates antidepressant-like activity with primary activity in the central nervous system.Several studies have shown that MCI-225 exhibits improvement in amnesia in scopolamine treated rats and in basal forebrain lesion rats. Acute administration of MCI-225 inhibits the rise of threshold induced by footshock stress1.It has been suggested that MCI-225 may affect attention, learning and memory2.