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Oroxylin A Europäischer Partner

ArtNr ALO-O-160-5mg
Hersteller Alomone
CAS-Nr. 0480-11-5
Menge 5 mg
Quantity options 100 mg 10 mg 25 mg 50 mg 5 mg
Kategorie
Typ Small Molecules
Format Lyophilized
Specific against other
Purity >98% (HPLC)
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Type
Non Antibodies
Manufacturer - Category
S. Molecules
Manufacturer - Targets
GABA(A) receptors
Country of Origin
Israel
Shipping Temperature
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions
Storage as Solution: Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted product for storage. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight
284, 26
Manufacturer - Format
Lyophilized powder.
Short description
An Antagonist of GABA(A) Receptors
Description
6-Methoxybaicalein, 5, 7-Dihydroxy-6-methoxyflavone - An Antagonist of GABA(A) Receptors
Reconstitution
Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity.
PH
7, 4
UNSPSC
41116134
Origin
Scutellaria baicalensis.
Effective Concentration
10 nM - 10 µM.
Activity
A flavonoid antagonist at the benzodiazepine site of the GABAA receptors. Inhibits [3H]Flunitrazepam binding to rat cerebral cortical membranes (IC50 = 1.09 µM), and selectively abolishes the anxiolytic, myorelaxant and motor incoordination, but not the sedative and anticonvulsant effects elicited by diazepam in mice1.
Solubility
Up to 50 mM in DMSO. Centrifuge all products before reconstitution (10000 x g 5 min).
Bioassay tested
Yes
Chemical Name
5, 7-dihydroxy-6-methoxy-2-phenylchromen-4-one.
Scientific Background
Oroxylin A, also called 6-Methoxybaicalein, is an antagonist at the benzodiazepine site of the GABA(A) receptors.Oroxylin A is an active O-methylated flavone compound that was originally isolated from the medicinal plant Scutellaria baicalensis. Oroxylin A was shown to have multiple functions, including anti-inflammatory, anti-cancer and anti-thrombotic activities. In addition, it has dopamine reuptake inhibitor activity and an inhibitory effect on nuclear factor-κB activation. The compound was used to treat pulmonary infection in Korea, China, and Japan1, 2.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA action, a major inhibitory neurotransmitter, through the central nervous system. The GABAA receptor is considered to be a major target of antiseizure drugs3.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 5 mg
Lieferbar: In stock
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