Ricasetron

Non Antibodies

5-HT3 receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

313, 22

A Potent Antagonist of 5-HT3 Receptors

Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity

41116134

Ricasetron is a 5-HT3 antagonist with Ki 0.32 nM1.

Yes

Ricasetron, also named BRL 46470A, is a highly potent and selective blocker of 5-HT3 channels. The compound shows no obvious affinity for other 5-HT receptor subtypes.In human, ricasetron demonstrates good absorption and tolerance with wide therapeutic range1.in vivo studies of several animal models of anxiety, Ricasetron showed a significant reduction in passive and provoked interaction responses following acute and chronic administration. These findings suggest that Ricasetron may have potent psychopharmacological properties that can contribute to treating anxiety1, 2.Studies show that Ricasetron is 100 times more potent than ondansetron, and 1000 times more potent than the standard anxiolytic diazepam in rat models. In these experiments the compound showed long duration of action1, 2.The 5-HT3 receptor mediates the action of serotonin in the body. This receptor is a member of the Cys-loop ligand-gated cation channels, which are expressed throughout the central and peripheral nervous systems and mediates a variety of physiological functions such as emotion, cognition, memory, pain perception, and gastrointestinal functions including secretion and motility3.