SR 57227A

Non Antibodies

Serotonin-gated channels

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

248, 15

A Potent and Selective Agonist of 5-HT3 Receptors

Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity

41116134

SR 57227A is a high affinity, selective 5-HT3 receptor agonist, active in vivo and CNS penetrant1.

Yes

SR 57227A is a compound with high affinity and selectivity for activating 5-HT3 receptors. It acts as an agonist for peripheral and central 5-HT3 receptors, both in vitro and in vivo, with IC50 values between 2.8 and 250 nM with no affinity for other subtypes of 5-HT.SD 57227A has the ability to cross the blood brain barrier, unlike many 5-HT3 receptors. Thus, SR 57227A can be used as a useful tool for characterizing the neuropharmacological effects produced by the stimulation of 5-HT3 receptors1.Some findings show that administration of SR 57227A can acutely induce and trigger movements and motor response in the hind limbs of adult paraplegic mice2.Additional findings indicate that SR 57227A exhibits antidepressant-like activity in rodent and decrease isolation induced aggressive behavior3.