SNAP 37889

Non Antibodies

Galanin 3 receptor

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

366, 34

A Selective Antagonist of Galanin 3 Receptor

Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).

41116134

SNAP 37889 is a potent GalR3 galanin receptor antagonist, highly selective for GalR3 (Ki = 17.44 nM) over GalR1 and GalR2 (Ki > 10 µM), showing anxiolytic and antidepressant-like effects in rodent models in vivo1-2.

Yes

SNAP 37889 is a potent and selective Galanin 3 receptor (GalR3) antagonist. The compound exists as E- and Z-isomers that interconvert quickly in solution at room temperature1, 2.Studies conducted in animals show that acute administration of SNAP 37889 enhances rat social interaction, reduces guinea pig vocalizations after maternal separation, and attenuates stress-induced hyperthermia in mice1.Galanin is a widely distributed neuropeptide that regulates various endocrine, pain and cognitive functions, including learning and memory in the central nervous system (CNS). It activates one of three receptors belonging to the GPCR superfamily: GalR1, GalR2 and GalR3. GAL3 receptors are involved in anxiety, depression, and drug-seeking behavior1, 2.