SR 48527

ArtNr	ALO-S-225-50mg
Hersteller	Alomone
CAS-Nr.	156579-04-3
Menge	50 mg
Quantity options	10 mg 25 mg 50 mg 5 mg
Kategorie	Metabolism Diabetes Glucose Homeostasis Reagents & Chemicals Molecules
Typ	Small Molecules
Format	Lyophilized
Specific against	other
Purity	>95%
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Non Antibodies
Manufacturer - Category	S. Molecules
Manufacturer - Targets	Neurotensin Receptor 1
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage as Solution: Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight	549
Manufacturer - Format	Lyophilized Powder
Short description	A Potent and Selective Antagonist of Neurotensin Receptor 1
Description	SR48527 - A Potent and Selective Antagonist of Neurotensin Receptor 1
Reconstitution	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
PH	7, 4
UNSPSC	41116134
Effective Concentration	1 nM - 1 µM.
Activity	SR 48527, an analog of SR 48692, is a potent and selective antagonist of NTS1 receptors, shown to inhibit neurotensin-stimulated IP production with Ki of 24 nM1, 2.
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Bioassay tested	Yes
Chemical Name	(2S)-2-[[1-(7-chloroquinolin-4-yl)-5-(2, 6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]-2-cyclohexylacetic acid.
Scientific Background	SR 48527 is a potent and selective antagonist of neurotensin receptor 1 (NTR1/NTS1). It is an analog of SR 48692 and inhibits neurotensin-stimulated IP production with a Ki value of 24 nM1, 2.The two neurotensin receptors, NTR1 and NTR2, belong to the family of G-protein-coupled receptors1, 2. The receptors are expressed in the brain and gastrointestinal tract where they play a role in pain transmission and intestinal motility.

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ALO-S-225-50mg-safety-datasheet.pdf