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TTA-P2 (S-enantiomer)

TTA-P2 (S-enantiomer)

ArtNr	ALO-T-210-5mg
Hersteller	Alomone
CAS-Nr.	1072018-68-8
Menge	5 mg
Quantity options	10 mg 1 mg 5 mg
Kategorie	Metabolism Cholesterol & Lipid Metabolism Lipid & Fatty Acid Transport Reagents & Chemicals Molecules
Typ	Small Molecules
Format	Lyophilized
Specific against	other
Purity	>99%
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Non Antibodies
Manufacturer - Category	S. Molecules
Manufacturer - Targets	CaV3 channels
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage as Solution: Up to four weeks at 4°C or three months at -20°C.
Molecular Weight	431
Manufacturer - Format	Lyophilized powder.
Short description	A Blocker of T-Type CaV Channels
Description	A Blocker of T-Type CaV Channels
Reconstitution	50 mM in DMSO. Centrifuge all product preparations before use (10, 000 x g for 1 min).
PH	7, 4
UNSPSC	41116134
Effective Concentration	0.05-10 µM.
Activity	TTA-P2 blocks T-type currents in DRGs with IC50 of 100 nM and 22 nM in thalamocortical and reticular neurons1, 2.
Solubility	50 mM in DMSO. Centrifuge all product preparations before use (10, 000 x g for 1 min).
Bioassay tested	Yes
Chemical Name	(S)-3, 5-Dichloro-N-((1-((2, 2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide.
Scientific Background	TTA-P2 is a novel, potent and selective T-type CaV channel blocker. In thalamocortical and reticular neurons, it blocks T-type currents with an IC50 of 22 nM without affecting high voltage Ca2+ channels1. In rat DRGs, it blocks T-type currents with an IC50 of 100 nM and stabilizes the channel in the inactive state2.TTA-P2 has the potential of acting as an antinociceptive agent2.

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ALO-T-210-5mg-safety-datasheet.pdf