Zacopride hydrochloride

Non Antibodies

5-HT3, 5-HT4 receptors

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

346, 25

A Potent Antagonist of 5-HT3 Receptors and an Agonist of 5-HT4 Receptors

100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM)1.

Yes

Zacopride hydrochloride is a derivative of benzamide, described as a potent 5-HT3 receptor antagonist with 5-HT4 receptor agonistic properties. Zacopride is a recemic compound. Studies showed that the S(-) form has a higher binding affinity for central and peripheral 5-HT3 receptor compared to R(+) zacopride1. Ki values for 5-HT3 and 5-HT4 receptors are 0.38 nM and 373 nM respectively3.There is some evidence from animal behavioral experiments that 5-HT3 receptor antagonists may be useful as anxiolytics, antipsychotics, cognition-enhancers and anti-addictive agents. It has been reported from these models that the S(-) enantiomer is potent in animal models of psychosis whereas the R(+) enantiomer is more potent in anxiety models1.Zacopride has been shown to be an effective anti-emetic agent against the emesis induced by cytotoxins and radiation in dogs, cats, non-human primates and ferrets2.