Otenzepad

102394-31-0

421.54

10 mM in DMSO

Neuronal Signaling; GPCR/G Protein

Otenzepad (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC₅₀ values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively^[1]. IC50 & Target: 640 nM (M2 muscarinic acetylcholine receptor in rabbit peripheral lung), 386 nM (M2 muscarinic acetylcholine receptor in rat heart)^[1]. In Vivo: Otenzepad (0.5, 1 mg/kg, s.c., in rats) significantly improved win-stay acquisition relative to vehicle-injected controls^[2].
Otenzepad (2 mg/kg, s.c., in rats) significantly improved retention relative to vehicle controls^[2].
Otenzepad (0.3, 1.0, or 3.0 mg/kg, ip, in mice) potentiates the effects of glucose and reverses the effects of insulin on memory^[3].