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Otenzepad

Otenzepad

Item no.	CS-0021266-5mg
Manufacturer	ChemScene
CASRN	102394-31-0
Amount	5mg
Category	Cardiovascular Research Hypertension Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	102394-31-0
Similar products	102394-31-0
Available
Alternative Names	AF-DX 116
CAS	102394-31-0
Purity	>98%
MWt	421.54
Formula	C24H31N5O2
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Neuronal Signaling; GPCR/G Protein
Target	mAChR; mAChR
Biological Activity	Otenzepad (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC₅₀ values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively^[1]. IC50 & Target: 640 nM (M2 muscarinic acetylcholine receptor in rabbit peripheral lung), 386 nM (M2 muscarinic acetylcholine receptor in rat heart)^[1]. In Vivo: Otenzepad (0.5, 1 mg/kg, s.c., in rats) significantly improved win-stay acquisition relative to vehicle-injected controls^[2]. Otenzepad (2 mg/kg, s.c., in rats) significantly improved retention relative to vehicle controls^[2]. Otenzepad (0.3, 1.0, or 3.0 mg/kg, ip, in mice) potentiates the effects of glucose and reverses the effects of insulin on memory^[3].
Research Area	Metabolic Disease; Neurological Disease

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