B022

1202764-53-1

397.88

DMSO : 250 mg/mL (628.33 mM; Need ultrasonic)

NF-kappaB

B022 is a potent and selective NF-kappaB-inducing kinase (NIK) inhibitor with a K_i of 4.2 nM. B022 protects liver from toxin-induced inflammation, oxidative stress, and injury^[1]. IC50 & Target: Ki: 4.2 nM (NF-kappaB-inducing kinase (NIK))^[1] In Vitro: B022 (0-5 uM; 12 hours; Hepa1 cells) treatment suppresses NIK-induced p52 formation in a dose-dependent manner^[1].
B022 (0-5 uM; 12 hours; Hepa1 cells) treatment for 8 h completely blocks NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5^[1]. In Vivo: B022 (30 mg/kg; intravenous injection; twice a day; for 10 days; STOP-NIK male mice) treatment inhibits NIK-triggered liver inflammation and injury in STOP-NIK mice infected with cre adenoviruses^[1].