B022

Manufacturer	ChemScene
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Amount	5mg
Item no.	CS-0078192-5mg
eClass 6.1	32169090
eClass 9.0	32169090
Available
CAS	1202764-53-1
Purity	>98%
MWt	397.88
Formula	C19H16ClN5OS
Solubility	DMSO : 250 mg/mL (628.33 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	NF-kappaB
Target	NF-kappaB
Biological Activity	B022 is a potent and selective NF-kappaB-inducing kinase (NIK) inhibitor with a K_i of 4.2 nM. B022 protects liver from toxin-induced inflammation, oxidative stress, and injury^[1]. IC50 & Target: Ki: 4.2 nM (NF-kappaB-inducing kinase (NIK))^[1] In Vitro: B022 (0-5 uM; 12 hours; Hepa1 cells) treatment suppresses NIK-induced p52 formation in a dose-dependent manner^[1]. B022 (0-5 uM; 12 hours; Hepa1 cells) treatment for 8 h completely blocks NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5^[1]. In Vivo: B022 (30 mg/kg; intravenous injection; twice a day; for 10 days; STOP-NIK male mice) treatment inhibits NIK-triggered liver inflammation and injury in STOP-NIK mice infected with cre adenoviruses^[1].
Research Area	Inflammation/Immunology

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Amount: 5mg

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Delivery expected until 6/6/2024