Syk Inhibitor II

726695-51-8

340.30

DMSO : 5 mg/mL (14.69 mM; Need ultrasonic)

Neuronal Signaling; GPCR/G Protein; Protein Tyrosine Kinase/RTK

Syk Inhibitor II is a potent, high selective and ATP-competitive Syk inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect^[1]. In Vitro: Syk Inhibitor II (compound 9a) shows less potent against PKCepsilon, PKCbeta2, ZAP-70, Btk, and Itk with IC₅₀ values of 5.1 uM, 11 uM, 11.2 uM, 15.5 uM, and 22.6 uM, respectively^[1]. In Vivo: Syk Inhibitor II (Compound 9a; 10-100 mg/kg) is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID₅₀ value of 13.2 mg/kg^[1].