NAE-IN-M22

864420-54-2

363.32

10 mM in DMSO

Apoptosis

NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo^[1]. IC50 & Target: NEDD8 activating enzyme (NAE)^[1] In Vitro: M22 (0.37-90 uM; 24 h) blocks neddylation pathway selectively and suppresses degradation of CRL substrates in A549 cells^[1].
M22 (0.1-100 uM; 48 h) inhibits A549 cell proliferation completely at 30 uM (GI₅₀=5.5 uM, GI₉₀=19.3 uM)^[1].
M22 (15-30 uM; 36 h) promotes apoptosis in A549 cell line^[1]. In Vivo: M22 (60 mg/kg; i.p. once daily for 14 d) inhibits tumor growth in nude mice bearing AGS xenografts^[1].
M22 (0.36-90 uM) has low acute toxicity in zebrafish model^[1].