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NAE-IN-M22

NAE-IN-M22

Manufacturer	ChemScene
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Amount	50mg
Item no.	CS-0087489-50mg
eClass 6.1	32169090
eClass 9.0	32169090
Available
CAS	864420-54-2
Purity	>98%
MWt	363.32
Formula	C20H24Cl2N2
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Apoptosis
Target	Apoptosis
Biological Activity	NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo^[1]. IC50 & Target: NEDD8 activating enzyme (NAE)^[1] In Vitro: M22 (0.37-90 uM; 24 h) blocks neddylation pathway selectively and suppresses degradation of CRL substrates in A549 cells^[1]. M22 (0.1-100 uM; 48 h) inhibits A549 cell proliferation completely at 30 uM (GI₅₀=5.5 uM, GI₉₀=19.3 uM)^[1]. M22 (15-30 uM; 36 h) promotes apoptosis in A549 cell line^[1]. In Vivo: M22 (60 mg/kg; i.p. once daily for 14 d) inhibits tumor growth in nude mice bearing AGS xenografts^[1]. M22 (0.36-90 uM) has low acute toxicity in zebrafish model^[1].
Research Area	Cancer

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Amount: 50mg

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Delivery expected until 7/4/2024