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sn-Glycero-3-phosphocholine

sn-Glycero-3-phosphocholine

ArtNr	TMO-T4439-500mg
Hersteller	TargetMol
CAS-Nr.	28319-77-9
Menge	500 mg
Quantity options	1 g 25 mg 500 mg
Kategorie	Reagents & Chemicals Molecules
Typ	Molecules
Specific against	other
Purity	99.00%
Citations	Parnetti L, et al. Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation J Neurol Sci. 2007 Jun 15;257(1-2):264-9.
Smiles	P(OC[C@@H](CO)O)(OCC[N+](C)(C)C)(=O)[O-]
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Choline glycerophosphate, Alpha-GPC, Glycerophosphocholine, Choline Alfoscerate, Glycerophosphorylcholine, L-α-GPC
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Targets	AChE\|\|\|Endogenous Metabolite
	ACHE
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	257, 22
Description	sn-Glycero-3-phosphocholine (Choline glycerophosphate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of Alzheimer's disease and dementia. sn-Glycero-3-phosphocholine rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer's disease. An Italian multicentre clinical trial on 2, 044 patients suffering from recent stroke were supplied Glycerylphosphorylcholine in doses of 1, 000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2].
Bioactivity	Glycerylphosphorylcholine is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of Alzheimer's disease and dementia. Glycerylphosphorylcholine rapidly delivers choline to the brain across the blood-brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer's disease. An Italian multicentre clinical trial on 2, 044 patients suffering from recent stroke were supplied Glycerylphosphorylcholine in doses of 1, 000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2].
Pathways	Metabolism\|\|\|Neuroscience

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