Bacitracin (Bacillus licheniformis) USP 65+ IU/mg

Blue Ice

1422, 71

White to pale powder

Bacitracin is a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Bacitracin also strongly inhibits proline endopeptidase from human muscle.

Grade:
USP

Synonyms:
N-[[(4R)-2-[(1S, 2S)-1-Amino-2-methylbutyl]-4, 5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-α-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-α-aspartyl-L-asparagine (10→4)-Lactam;
Altracin; Ayfivin; Baciguent; Bacillichin; Bacilliquin; Fortracin; Parentracin; Penitracin; Topitracin; Tropitracin; Zutracin

CAS No:
1405-87-4

Molecular Formula:
C₆₆H₁₀₃N₁₇O₁₆S

Molecular Weight:
1422.71

Appearance:
White to pale powder

Assay (Anhydrous basis):
≥65 IU/mg (Bacitracin)

Identification (TLC):
Conforms to standard

Melting Point:
221-225°C (lit)

Bacitracin A Content:
≥40%

Active Bacitracin Content:
≥70%

Bacitracin F:
≤6%

Early Eluting Peptides:
≤20%

pH:
5.5 -7.5

Solubility:
Colorless, clear solution with frequent agitation

Loss on Drying:
≤5%

Residue on Ignition:
≤0.5%

Microbial Count:
≤100cfu/g

Storage and Stability:
Store at -20ºC. Stable for 12 months after receipt. Hygroscopic; protetect from moisture.