Apoptosis Activator 2

Description: Apoptosis Activator 2 is a novel and potent small molecule apoptosis activator with IC50 value of about 4uM. Apoptosis Activator 2 is a cell permeable compound that promotes apoptosis by activating caspases in a cytochrome c- and Apaf-1-dependent manner. 20uM Apoptosis Activator 2 increases the fraction of Apaf-1 in the apoptosome when there is 0.15uM cytochrome c. Apoptosis Activator 2 was found to induce the oligomerization of Apaf-1. Through the induction of apoptosis, Apoptosis Activator 2 notably induces caspase-3 activation, PARP cleavage and DNA fragmentation.

References: Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7533-8; Neural Dev. 2009 Mar 16; 4:11.