CCT128930

Description: CCT128930 is a novel, potent, ATP-competitive and selective pyrrolopyrimidine-based inhibitor of Akt2 (IC50 = 6 nM in a cell-free assay) with potential anticancer activity. It showed 28-fold greater selectivity for Akt2 over the closely related PKA kinases. CCT128930 was discovered through fragment- and structure-based drug design approaches. CCT128930 exhibited marked antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition. In conclusion, CCT128930 is a novel, potent and selective AKT inhibitorthat blocks AKT activity in vitro and in vivo and induces markedantitumor responses.

References: Mol Cancer Ther. 2011 Feb; 10(2):360-71.

Synonym: CCT128930; CCT-128930; CCT 128930.

Chemical Name: 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)piperidin-4-amine

SMILES Code: NC1(CC2=CC=C(Cl)C=C2)CCN(C3=C4C(NC=C4)=NC=N3)CC1