Tacrolimus (FK-506, Fujimycin, FR900506, Prograf)

Description: Tacrolimus (FK506, Fujimycin, FR-900506, Prograf), a natural macrocyclic lactone isolated from the fungus Streptomyces tsukubaensis, is a potent immunosuppressive agent used with other medications to prevent rejection of organ (kidney, heart, liver) transplant. It acts by binding to FK506 binding protein (FKBP) and is an inhibitor of calcineurin phosphatase, leading to inhibition of T-lymphocyte signal transduction and IL-2 transcription.Tacrolimus can reduce the activity of the patient's immune system and to lower the risk of organ rejection. It is also used in a topical preparation in the treatment of atopic dermatitis (eczema), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, TH2-mediated diseases such as Kimura's disease, and the skin condition vitiligo.

References: Nature. 1991 Aug 29; 352(6338):803-7; Nature. 1992 Jun 25; 357(6380):692-4.

Related CAS: 109581-93-3 (hydrate); 132172-14-6 L 683519 (Tacrolimus Impurity)