PF-4708671

ArtNr	V0239-500mg
Hersteller	InvivoChem LLC
CAS-Nr.	1255517-76-0
Menge	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg
Kategorie	Cardiovascular Research Hypertension Reagents & Chemicals Molecules
Typ	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
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Description	InvivoChem Cat #:V0239CAS #:1255517-76-0Purity >=98% Description: PF-4708671 is a novel, potent, highly specific and cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform)/RSK1 with potential antitumor activity. It inhibits RSK1 with a Ki/IC50 of 20 nM/160 nM in cell-free assays, exhibits 400-fold greater selectivity for S6K1 over S6K2, and displays 4- and > 20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. As the first S6K1-specific inhibitor reported, PF-4708671 showed potent antiproliferative activity in vitro and high antitumor efficacy in vivo by preventing the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. Description: Description: PF-4708671 is a novel, potent, highly specific and cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform)/RSK1 with potential antitumor activity. It inhibits RSK1 with a Ki/IC50 of 20 nM/160 nM in cell-free assays, exhibits 400-fold greater selectivity for S6K1 over S6K2, and displays 4- and > 20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. As the first S6K1-specific inhibitor reported, PF-4708671 showed potent antiproliferative activity in vitro and high antitumor efficacy in vivo by preventing the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. References:Biochem J. 2010 Oct 15; 431(2):245-55. References:References:

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Menge: 500 mg

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Lieferung vsl. bis 02.10.2025

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