ec-17-free-acid

Description: EC17 (Folate-FITC) is a fluorescein isothiocyanate (FITC) conjugated folic acid with potential antineoplastic activity. It also acts as a FRalpha-targeting agent that fluoresces at 500nm. EC17 is conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic activity. Folate-FITC binds to folate receptors, which are overexpressed on the surfaces of many cancer cells including kidney and ovarian cancer cells. Once bound to the cancer cell through the folate moiety of the conjugate, curculating anti-fluorescein antibodies.may recognize and bind to the FITC moiety, resulting in antibody-dependent cellular cytotoxicity.

References: Kikuchi A, Yanase T, Sasagawa M, Honma S. The role of para-aortic lymphadenectomy in stage IIIC endometrial cancer: A single-institute study. J Obstet Gynaecol. 2017 May; 37(4):510-513.

Related CAS #: 910661-33-5 (sodium); 583037-91-6 (acid)