Vardenafil HCl

Description:Vardenafil HCl, also known as BAY 38-9456 HCl, is a novel and potent PDEinhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.Vardenafil is used for treating erectile dysfunction. Vardenafil (VAR)is synthetic, highly selective, and potent inhibitor ofphosphodiesterase-5 which competitively inhibits cyclic guanosinemonophosphate (cGMP) hydrolysis and thus increases cGMP levels. It isclinically approved for treatment of erectile dysfunction in men, including diabetic and postprostatectomy patients. Vardenafil'sindications and contraindications are the same as with other PDE5inhibitors; it is closely related in function to sildenafil citrate(Viagra) and tadalafil (Cialis). The difference between the vardenafilmolecule and sildenafil citrate is a nitrogen atom's position and thechange of sildenafil's piperazine ring methyl group to an ethyl group.Tadalafil is structurally different from both sildenafil and vardenafil.Vardenafil's relatively short effective time is comparable to butsomewhat longer than sildenafil's.

References: Int J Impot Res. 2001 Oct; 13(5):282-90; Neuroscience. 2002; 113(2):351-61.

Related CAS:224785-90-4 (free base); 224789-15-5 (2HCl); 330808-88-3 (HCl trihydrate)