Dexanabinol

Description: HU-211 (Dexanabinol) is a novel, potent synthetic terpene-based cannabinoid devoid of central cannabinoid (CB1) and peripheral cannabinoid (CB2) agonist activity, thus lacking the psychomotor responses characteristic of delta9-THC. HU-211 does exhibit the neuroprotective, antioxidant properties of other related compounds like cannabidiol. HU-211 also has anti-inflammatory properties derived through inhibition of NF-kappaB and the resulting decreases in cytokines such as TNFalpha and interleukin-6. The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.

References: Neuropharmacology 47, 580-592 (2004).

Chemical Name: (6aS, 10aS)-9-(Hydroxymethyl)-6, 6-dimethyl-3-(2-methyloctan-2-yl)-6a, 7, 10, 10a-tetrahydrobenzo[c]chromen-1-ol;

SMILES Code: OC1=CC(C(CCCCCC)(C)C)=CC2=C1[C](CC(CO)=CC3)([H])[C]3([H])C(C)(C)O2