amg-232

InvivoChem Cat #:V3460CAS #:1352066-68-2 Purity >=98%

Description: AMG 232 is a novel, potent, selective and orally bioavailable piperidinone inhibitor of MDM2-p53 protein-protein interaction with IC50 of 0.6 nM. AMG 232 binds to MDM2 with a Kd of 0.045 nM. AMG 232 is currently being evaluated in human clinical trials for the treatment of cancer. p53 is a critical tumor suppressor and is the most frequently inactivated gene in human cancer. Inhibition of the interaction of p53 with its negative regulator MDM2 represents a promising clinical strategy to treat p53 wild-type tumors. AMG 232 is a potential best-in-class inhibitor of the MDM2-p53 interaction and is currently in clinical trials for multiple tumor indications.

References: J Med Chem. 2014 Aug 14; 57(15):6332-41.; Mol Cancer Ther. 2015 Mar; 14(3):649-58.; Xenobiotica. 2015; 45(8):681-92.

-20C for 3 years in powder form

Synonym: AMG232; AMG-232; AMG 232.
Chemical Name: 2-((3R, 5R, 6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
InChi Key: DRLCSJFKKILATL-YWCVFVGNSA-N
InChi Code: InChI=1S/C28H35Cl2NO5S/c1-17(2)24(16-37(35, 36)18(3)4)31-26(19-9-11-21(29)12-10-19)23(20-7-6-8-22(30)13-20)14-28(5, 27(31)34)15-25(32)33/h6-13, 17-18, 23-24, 26H, 14-16H2, 1-5H3, (H, 32, 33)/t23-, 24-, 26-, 28-/m1/s1
SMILES Code: CC(C)S(C[CH](C(C)C)N(C1=O)[CH]([CH](C[C]1(CC(O)=O)C)C2=CC=CC(Cl)=C2)C3=CC=C(C=C3)Cl)(=O)=O