Comparison

amg-232

Item no. V3460-5mg
Manufacturer InvivoChem LLC
CASRN 1352066-68-2
Amount 5mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 1352066-68-2
Available
Description
InvivoChem Cat #:V3460CAS #:1352066-68-2 Purity >=98%

Description: AMG 232 is a novel, potent, selective and orally bioavailable piperidinone inhibitor of MDM2-p53 protein-protein interaction with IC50 of 0.6 nM. AMG 232 binds to MDM2 with a Kd of 0.045 nM. AMG 232 is currently being evaluated in human clinical trials for the treatment of cancer. p53 is a critical tumor suppressor and is the most frequently inactivated gene in human cancer. Inhibition of the interaction of p53 with its negative regulator MDM2 represents a promising clinical strategy to treat p53 wild-type tumors. AMG 232 is a potential best-in-class inhibitor of the MDM2-p53 interaction and is currently in clinical trials for multiple tumor indications.

References: J Med Chem. 2014 Aug 14; 57(15):6332-41.; Mol Cancer Ther. 2015 Mar; 14(3):649-58.; Xenobiotica. 2015; 45(8):681-92.

AMG 232

Name: AMG-232
CAS#: 1352066-68-2
Chemical Formula: C28H35Cl2NO5S
Exact Mass: 567.1613
Molecular Weight: 568.55
Elemental Analysis: C, 59.15; H, 6.20; Cl, 12.47; N, 2.46; O, 14.07; S, 5.64
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Technical Information
Synonym: AMG232; AMG-232; AMG 232.
Chemical Name: 2-((3R, 5R, 6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
InChi Key: DRLCSJFKKILATL-YWCVFVGNSA-N
InChi Code: InChI=1S/C28H35Cl2NO5S/c1-17(2)24(16-37(35, 36)18(3)4)31-26(19-9-11-21(29)12-10-19)23(20-7-6-8-22(30)13-20)14-28(5, 27(31)34)15-25(32)33/h6-13, 17-18, 23-24, 26H, 14-16H2, 1-5H3, (H, 32, 33)/t23-, 24-, 26-, 28-/m1/s1
SMILES Code: CC(C)S(C[CH](C(C)C)N(C1=O)[CH]([CH](C[C]1(CC(O)=O)C)C2=CC=CC(Cl)=C2)C3=CC=C(C=C3)Cl)(=O)=O

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5mg
Available: In stock
available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close