MK-393

InvivoChem Cat #: V4058
CAS #: 1219737-12-8
Purity >=98%



Description:
MK-3903 is a novel, potent and selective AMPK (AMP-activated protein kinase) activator with EC50 of 8 nM for alpha1 beta1 gamma1 subunit. It activates 10 of the 12 pAMPK complexes with EC50 values in the range of 8-40 nM and maximal activation > 50%. MK-3903 exhibited robust target engagement in mouse liver following oral dosing, leading to improved lipid metabolism and insulin sensitization in mice. Chronic oral administration of MK-3903 robustly increased ACC phosphorylation in liver with more modest effects in skeletal muscle. Treatment of various mouse models with MK-3903 resulted in expected alterations in lipid metabolism and improvements in a measure of insulin sensitization.

Description:

References:
J Med Chem. 2017 Nov 9; 60(21):9040-9052.

References:

C27H19ClN2O3

-20C for 3 years in powder form
-80C for 2 years in solvent

5-((5-([1, 1?-biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid

O=C(O)C1=CC(OC2=NC3=CC(C4=CC=C(C5=CC=CC=C5)C=C4)=C(Cl)C=C3N2)=CC=C1C