Litronesib

InvivoChem Cat #:V4905CAS #:910634-41-2Purity >=98%

Description: Litronesib (formerly also known as LY2523355) is a novel, potent and selective inhibitor of the kinesin-related motor protein Eg5 with potential anticancer activity. Litronesib selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein that plays an essential role during mitosis, particularly in the regulation of spindle dynamics, including assembly and maintenance. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

References: Mol Cancer Ther. 2015 Nov; 14(11):2463-72.

-20C for 3 years in powder form

Synonym: LY2523355; LY-2523355; LY 2523355; KF89617; KF-89617; KF 89617; Eg5 KinesinRelated Motor Protein Inhibitor .
IUPAC/Chemical Name: (R)-N-(5-((2-(ethylamino)ethylsulfonamido)methyl)-5-phenyl-4-pivaloyl-4, 5-dihydro-1, 3, 4-thiadiazol-2-yl)pivalamide.
InChi Key: YVAFBXLHPINSIK-QHCPKHFHSA-N
InChi Code: InChI=1S/C23H37N5O4S2/c1-8-24-14-15-34(31, 32)25-16-23(17-12-10-9-11-13-17)28(19(30)22(5, 6)7)27-20(33-23)26-18(29)21(2, 3)4/h9-13, 24-25H, 8, 14-16H2, 1-7H3, (H, 26, 27, 29)/t23-/m0/s1
SMILES Code: CC(C)(C)C(NC1=NN(C(C(C)(C)C)=O)[C](C2=CC=CC=C2)(CNS(=O)(CCNCC)=O)S1)=O