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Rat NKG2A&CD94 Protein, Mouse IgG2a Fc Tag (MALS verified) Europäischer Partner

ArtNr NC4-R5258-1mg
Hersteller ACROBiosystems
Menge 500 ug x 2
Quantity options 100 ug 500 ug x 2
Kategorie
Typ Proteins Recombinant
Format Solid
Specific against Rat (Rattus norvegicus)
Host HEK293
Isotype IgG2a
Konjugat/Tag Unconjugated, C-mFc
Purity 95%
Formula PBS, pH7.4
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Category
Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag
C-mFc(mIgG2a), Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
61.0 kDa
Manufacturer - Format
Powder
Description
Rat NKG2A&CD94 Protein, Mouse IgG2a Fc Tag (NC4-R5258) is expressed from human 293 cells (HEK293). It contains AA Thr 90 - Asn 231 (NKG2A) & Lys 32 - Thr 179 (CD94) (Accession # O54872-1(NKG2A) & O35778-1(CD94)).
Background
CD94 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. NKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors that inhibits innate immune system activation. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.
Molecule
NKG2A & CD94
Exp Region
Thr 90 - Asn 231 (NKG2A) & Lys 32 - Thr 179 (CD94)
Characteristics
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 61.0 kDa. The protein migrates as 67-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
PBS, pH7.4
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug x 2
Lieferbar: In stock
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