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Recombinant human IL-15R alpha/IL15RA protein

ArtNr NKM-ATGP3672-500ug
Hersteller NKMAX
Menge 500 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host Baculovirus-Infected Insect Cells
Konjugat/Tag HIS
Purity > 90% by SDS-PAGE
Sequence <ADP>ITCPPPM SVEHADIWVK SYSLYSRERY ICNSGFKRKA GTSSLTECVL NKATNVAHWT TPSLKCIRDP ALVHQRPAPP STVTTAGVTP QPESLSPSGK EPAASSPSSN NTAATTAAIV PGSQLMPSKS PSTGTTEISS HESSHGTPSQ TTAKNWELTA SASHQPPGVY PQGHSDTT<LE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV
Citations Epardaud M., et al, (2008) Cancer Res. 68:2972-2983.
Stoklasek TA., et al, (2006) J Immunol. 177:6072-6080.
NCBI NP_002180
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Interleukin-15 receptor subunit alpha isoform 1,IL15RA,CD215,IL-15 receptor subunit alpha
Similar products IL15 R a, ATGP3672-10ug, ATGP3672-20ug, ATGP3672-50ug, ATGP3672-100ug, ATGP3672-250ug, ATGP3672-500ug, ATGP3672-1mg, ATGP3672-10, ATGP3672-20, ATGP3672-50, ATGP3672-100, ATGP3672-250, ATGP3672-500, ATGP3672-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Bioactivity
Manufacturer - Conjugate / Tag
hIgG-His-Tag
Manufacturer - Host
Baculovirus
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
45.6 kDa (417aa)
Description
IL15RA, also known as interleukin-15 receptor subunit alpha isoform 1, is a high-affinity receptor for interleukin-15. It associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. This protein can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. IL15/IL15R alpha complexes can transmit reverse signaling that promotes cellular adhesion, tyrosine phosphorylation of intracellular proteins, and cytokine secretion by the IL 15/IL15R alpha expressing cells. Recombinant human IL15RA protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Concentration
0.5mg/ml (determined by absorbance at 280nm)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species
Human
Gene Category
Apoptosis
Domain
31-205aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured by its ability to inhibit proliferation using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is ≤2ng/ml with Human IL-15.
Predicted nterm
Ala
Species of Protein
Human
Manufacturer - Search Terms
IL15 R a, ATGP3672-10ug, ATGP3672-20ug, ATGP3672-50ug, ATGP3672-100ug, ATGP3672-250ug, ATGP3672-500ug, ATGP3672-1mg, ATGP3672-10, ATGP3672-20, ATGP3672-50, ATGP3672-100, ATGP3672-250, ATGP3672-500, ATGP3672-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug
Lieferbar: In stock
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