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Recombinant human TGF-beta RI/ALK-5 protein

ArtNr NKM-ATGP4134-50ug
Hersteller NKMAX
Menge 50 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host Baculovirus-Infected Insect Cells
Konjugat/Tag HIS
Purity > 90% by SDS-PAGE
Sequence <ADL>LLPGATA LQCFCHLCTK DNFTCVTDGL CFVSVTETTD KVIHNSMCIA EIDLIPRDRP FVCAPSSKTG SVTTTYCCNQ DHCNKIELPT TVKSSPGLGP VEL<VEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG
Citations Wrana JL., et al, (1992) Cell 71:1003-1014.
Huse M., et al, (1999) Cell 96:425-436.
NCBI NP_004603.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Lieferbar
Manufacturer - Type
Proteins
Manufacturer - Applications
SDS-PAGE, Bioactivity
Manufacturer - Category
Recombinant Protein
Manufacturer - Conjugate / Tag
hIgG-His-Tag
Manufacturer - Host
Baculovirus
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
38kDa (342aa)
Description
TGFBR1, also known as TGF-beta receptor type-1 isoform 1, is a single-pass type 1 membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. This protein is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. Also, it plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A), Loeys-Diets syndrome type 2A (LDS2A), and aortic aneurysm familial thoracic type 5 (AAT5). Recombinant human TGFBR1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Concentration
0.5mg/ml (determined by absorbance at 280nm)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species
Human
Gene Category
Signal Transduction, Angiogenesis, Cardiovascular
Domain
27-126aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured by its binding ability in a functional ELISA with Mouse CD105 (CAT# ATGP3361). The ED50 range ≤ 2 ug/ml.
Predicted nterm
Ala
Species of Protein
Human
Manufacturer - Search Terms
ATGP4134-10ug, ATGP4134-20ug, ATGP4134-50ug, ATGP4134-100ug, ATGP4134-250ug, ATGP4134-500ug, ATGP4134-1mg, ATGP4134-010, ATGP4134-020, ATGP4134-050, ATGP4134-100, ATGP4134-250, ATGP4134-500, ATGP4134-01M, ATGP3735-10ug, ATGP3735-20ug, ATGP3735-50ug, ATGP3735-100ug, ATGP3735-250ug, ATGP3735-500ug, ATGP3735-1mg, ATGP3735, ATGP3735-020, ATGP3735-050, ATGP3735-100, ATGP3735-250, ATGP3735-500, ATGP3735-01M
Manufacturer - Alternative Names
TGF-beta receptor type-1 isoform 1, TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TBR-I, TBRI, TGFR-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, Serine/threonine-protein kinase receptor R4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I
Manufacturer - Similar Names
ATGP4134-10ug, ATGP4134-20ug, ATGP4134-50ug, ATGP4134-100ug, ATGP4134-250ug, ATGP4134-500ug, ATGP4134-1mg, ATGP4134-010, ATGP4134-020, ATGP4134-050, ATGP4134-100, ATGP4134-250, ATGP4134-500, ATGP4134-01M, ATGP3735-10ug, ATGP3735-20ug, ATGP3735-50ug, ATGP3735-100ug, ATGP3735-250ug, ATGP3735-500ug, ATGP3735-1mg, ATGP3735, ATGP3735-020, ATGP3735-050, ATGP3735-100, ATGP3735-250, ATGP3735-500, ATGP3735-01M

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ug
Lieferbar: In stock
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