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Recombinant human IL-33 protein

ArtNr NKM-ILC0701-50ug
Hersteller NKMAX
Menge 50 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag Untagged
Purity > 95% by SDS-PAGE
Sequence MSITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET
Citations Schmitz., et al. (2005) immunity 23(5):479-90
Baekkevold, E.S., et al. (2003) Am. J.Pathol. 163(1):69-90

Ito R, et al. A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis. (JCI Insight. 2018){https://pubmed.ncbi.nlm.nih.gov/30385714/}
NCBI NP_254274
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Interleukin-33,Interleukin-1 family member 11,IL-1F11,Nuclear factor from high endothelial venules,NF-HEV,DVS27-related protein,DVS27,C9orf26
Similar products IL-33, IL33, C9orf26, IL1F11, NFHEV, Nuclear factor from high endothelial venules, DKFZp586H0523, DVS27, NF-HEV, IL 33, DVS27 related protein, IL 1F11, Interleukin 1 family member 11, Interleukin 33, Interleukin 33 precursor, Interleukin33, NF HEV, RP11 575C20.2, NKHEV, Interleukin 33 CHROMOSOME 9 OPEN READING FRAME 26, INTERLEuKIN 33 NFHEV, il33, ILC0701-10ug, ILC0701-20ug, ILC0701-50ug, ILC0701-100ug, ILC0701-250ug, ILC0701-500ug, ILC0701-1mg, ILC0701-10, ILC0701-20, ILC0701-50, ILC0701-100, ILC0701-250, ILC0701-500, ILC0701-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Bioactivity
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
18.1 kDa (160aa) confirmed by MALDI-TOF
Description
Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1. Recombinant human IL-33(C-terminal fragment) was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0)
Antigen Species
Human
Gene Category
Hormones & Cytokines
Domain
112-270aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 range ≤ 0.3ng/ml.
Species of Protein
Human
Manufacturer - Search Terms
IL33, Interleukin 33, DVS27, NF-HEV, NKHEV, C9orf26, IL-33, Interleukin 33 CHROMOSOME 9 OPEN READING FRAME 26, DKFZp586H0523, DVS27 related protein, IL 1F11, IL 33, IL1F11, Interleukin 1 family member 11, INTERLEuKIN 33 NFHEV, Interleukin 33 precursor, Interleukin33, NF HEV, NFHEV, Nuclear factor from high endothelial venules, RP11 575C20.2, il33, ILC0701-10ug, ILC0701-20ug, ILC0701-50ug, ILC0701-100ug, ILC0701-250ug, ILC0701-500ug, ILC0701-1mg, ILC0701-10, ILC0701-20, ILC0701-50, ILC0701-100, ILC0701-250, ILC0701-500, ILC0701-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ug
Lieferbar: In stock
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