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Human IL-6 antibody

ArtNr NKM-ATGA0313-100ul
Hersteller NKMAX
Menge 100 ul
Quantity options 100 ul 50 ul
Kategorie
Typ Antibody Monoclonal
Format Liquid
Applikationen WB, ELISA
Clon AT1F10
Specific against Human (Homo sapiens)
Host Mouse
Isotype IgG1 Kappa
Konjugat/Tag Unconjugated
Citations Heinrich P.C., et al. (1998) Biochem J 334: 297-314
Heinrich P.C., et al. (1998) Z Ernahrungswiss 37: 43-49
Jones S.A. (2005) J Immunol 175: 3463-3468
NCBI NP_000591
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Interleukin-6,B-cell stimulatory factor 2,BSF-2,CTL differentiation factor,CDF,Hybridoma growth factor,Interferon beta-2,IFN-beta-2,IFNB2,HGF,HSF
Similar products IL-6, HGF, IL6, IFNB2, Interleukin-6, FNRB, MDF2, MSK12, Fibronectin receptor subunit beta, CD29, Interleukin 6, IL 6, GPIIA, Integrin beta 1, BSF2, HSF, VLAB, Integrin beta1, BSF 2, Interferon beta 2, Interleukin6, VLA-4 subunit bet, VLA4 subunit bet, VLA 4 subunit bet, MSK 12, IFNB 2, IFN B2, IFN B 2, I L6, GP IIA, Glycoprotein Iia, ATGA0313-10ug, ATGA0313-20ug, ATGA0313-50ug, ATGA0313-100ug, ATGA0313-250ug, ATGA0313-500ug, ATGA0313-1mg, ATGA0313-010, ATGA0313-020, ATGA0313-050, ATGA0313-100, ATGA0313-250, ATGA0313-500, ATGA0313-01M
Lieferbar
Manufacturer - Type
Monoclonal Antibody
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Description
Interleukin-6, or IL-6, is a multifunctional protein, 212 amino acids in length that plays critical roles in host defense, immune response and hematopoiesis. interleukin-6 (IL-6) produced by T cells, macrophages, fibroblasts, endothelial and other cells. IL-6 induces proliferation or differentiation in many cell types including B cells, thymocytes and T cells. IL-6, in concert with TGF-Beta, is important for developing Th17 responses. The IL-6 receptor is a trimeric complex composed of an IL-6-specific a chain and a homodimer of the gp130 glycoprotein common to the IL-6, IL-11, CNTF, OSM and LIF receptors. Stimulation with IL-6 leads to gp130 homodimerization and the activation of associated kinases JAK1 and JAK2. Once activated, JAK1 and JAK2 phosphorylate Stat3, causing its nuclear translocation and transcription of Stat3-responsive genes. IL-6 has also been shown to activate the Ras/MAP kinase pathway, which regulates NFIL6 transcription.
Concentration
1mg/ml (determined by BCA assay)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Immunogen
Recombinant human Interleukin 6 (30-212aa) purified from E. coli
Ab Usage
The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
Antigen Species
Human
Clonality
Monoclonal
Ab Purification Comment
By protein-A affinity chromatography
Gene Category
Hormones & Cytokines
Manufacturer - Search Terms
VLAB, VLA-4 subunit bet, VLA4 subunit bet, VLA 4 subunit bet, MSK12, MSK 12, MDF2, Interleukin-6, Interleukin6, Interleukin 6, Interferon beta 2, Integrin beta1, Integrin beta 1, IL-6, IL6, IL 6, IFNB2, IFNB 2, IFN B2, IFN B 2, I L6, HSF, HGF, GPIIA, GP IIA, Glycoprotein Iia, FNRB, Fibronectin receptor subunit beta, CD29, BSF2, BSF 2, ATGA0313-10ug, ATGA0313-20ug, ATGA0313-50ug, ATGA0313-100ug, ATGA0313-250ug, ATGA0313-500ug, ATGA0313-1mg, ATGA0313-010, ATGA0313-020, ATGA0313-050, ATGA0313-100, ATGA0313-250, ATGA0313-500, ATGA0313-01M

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ul
Lieferbar: In stock
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