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Recombinant human Bcl-2 protein

ArtNr NKM-ATGP0297-100ug
Hersteller NKMAX
Menge 100 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 90% by SDS-PAGE
Sequence MGSSHHHHHH SSGLVPRGSH MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY LNRHLHTWIQ DNGGWDAFVE LYGPSMRPLF D
Citations Zamzami N., et al. (1998) Oncogene. 16(17):2265-82.
Fernandez-Sarabia MJ., et al. (1993) Nature. 366(6452):274-5.

Jung SH, et al. Integrative proteomic profiling of protein activity and interactions using protein arrays. (Mol Cell Proteomics. 2012){https://pubmed.ncbi.nlm.nih.gov/22843993/}
Jung SH, et al. Identification of transglutaminase 2 kinase substrates using a novel on-chip activity assay. (Biosens Bioelectron. 2016){https://pubmed.ncbi.nlm.nih.gov/27040940/}
Jung SH, et al. Systematic investigation of protein kinase A substrate proteins using on-chip protein kinase kinetic profiling. (Analyst. 2017){https://pubmed.ncbi.nlm.nih.gov/28536714/}
NCBI NP_000624
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias BCL2 apoptosis regulator,B-cell CLL/lymphoma 2,PPP1R50,protein phosphatase 1,regulatory subunit 50
Similar products Bcl-2, 2, Bcl2, B-cell, Apoptosis regulator Bcl2, AW986256, B cell CLL/lymphoma 2, B cell leukemia/lymphoma 2, C430015F12Rik, D630044D05Rik, D830018M01Rik, Leukemia/lymphoma, Oncogene B-cell leukemia 2., B-cell lymphoma protein 2 alpha, B-cell lymphoma protein 2 alpha Apoptosis regulator Bcl 2, ATGP0297-10ug, ATGP0297-20ug, ATGP0297-50ug, ATGP0297-100ug, ATGP0297-250ug, ATGP0297-500ug, ATGP0297-1mg, ATGP0297-10, ATGP0297-20, ATGP0297-50, ATGP0297-100, ATGP0297-250, ATGP0297-500, ATGP0297-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
25.4 kDa (231aa) confirmed by MALDI-TOF
Description
Bcl-2, also known as B-cell lymphoma protein 2 alpha, is an anti-apoptotic protein located primarily in the outer mitochondrial membrane that blocks the apoptotic death of some cells such as lymphocytes. BCL-2 is thought to regulate cell death by controlling the mitochondrial membrane permeability during apotosis. Bcl-2 exerts its anti-apoptotic function through inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). The Bcl-2 gene has been related with a number of cancers, including melanoma, breast, prostate, and lung carcinomas, as well as schizophrenia and autoimmunity. Recombinant Bcl-2 protein was expressed in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Concentration
0.25mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol 2mM DTT
Antigen Species
Human
Gene Category
Cancer
Domain
1-211aa
Species of Protein
Human
Manufacturer - Search Terms
Bcl2, B-cell lymphoma protein 2 alpha, B-cell lymphoma protein 2 alpha, B-cell lymphoma protein 2 alpha Apoptosis regulator Bcl 2, Apoptosis regulator Bcl2, AW986256, B cell CLL/lymphoma 2, B cell leukemia/lymphoma 2, Bcl-2, Bcl2, C430015F12Rik, D630044D05Rik, D830018M01Rik, Leukemia/lymphoma, B-cell, 2, Oncogene B-cell leukemia 2., ATGP0297-10ug, ATGP0297-20ug, ATGP0297-50ug, ATGP0297-100ug, ATGP0297-250ug, ATGP0297-500ug, ATGP0297-1mg, ATGP0297-10, ATGP0297-20, ATGP0297-50, ATGP0297-100, ATGP0297-250, ATGP0297-500, ATGP0297-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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